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The lower proportion of WT cells in this animal was supported by their coat color chimerism Movie S3. In the present study, we used model pigs for three types of XLGDs: In the present study, the normal growth of the chimeric boar to adulthood proved that the chimerism induced by exogenous normal cells cured the muscle dysfunction of the DMD pig, at least to some extent. We demonstrated that induced chimerism rescued the lethal congenital symptoms of gene-knockout KO pigs for three types of XLGDs: In addition, characteristic age-related proteome changes were apparent in this model For instance, injecting Rag-2—deficient mouse blastocysts with normal ES cells led to the generation of somatic chimeras with normal B and T lymphocytes

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S3 D and histological analysis Fig.

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Such sexual reproduction systems using a stud male or his sperm have proven highly efficient for proliferating valuable animals throughout the history of animal husbandry. Deficiency of the thymus was also confirmed through autopsy of full-term fetuses Fig. Footnotes Conflict of interest statement: In the present study, the normal growth of the chimeric boar to adulthood proved that the chimerism induced by exogenous normal cells cured the muscle dysfunction of the DMD pig, at least to some extent. An assay of gene function in lymphocyte development.

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