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Of these two genes, only KLF10 is known to play an important role in immune regulation. A GFP expression construct was used as a positive control. Using a sliding window algorithm to calculate the mean and standard deviation within a window surrounding each data point, and define a z-score where z measures the number of standard deviations a data point is from the mean. These results are in concordance with the results obtained in our cell line studies. Given that KLFspecific small molecule inhibitors have been developed and are known to elicit potent effects in T cells 36such drugs could represent a novel treatment for CC. These two genes were previously described to be up-regulated in CC by our group

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Importantly, the recurrence of specific aberrations both amplifications and deletions at particular sites in the genome indicates that such sites are likely to harbor genes whose alteration favors neoplastic progression 2.

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Functional role of KLF10 in multiple disease processes. The Kattner family began attaining art in the s, and in the decades since, have amassed a collection of paintings and drawings by prominent 19th and 20th century American artists. These two genes were previously described to be up-regulated in CC by our group Introduction Cervical cancer CC is currently the second most common cancer among the female population 1. As is the case with many other cancer types, host immune system evasion, involving the failure of the immune system to resist or eradicate formation and progression of incipient neoplastic cells, late-stage tumors and micro-metastasis is problematic in CC 2. As shown in Fig. Redbird Rumble 1.

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